Critical limb ischemia (CLI) refers to severe compromise of blood flow to alimb (hands or legs) which causes severe limb pain at rest or even loss of limb. It is the most advanced form of peripheral artery disease.
Prevalent in 2% patient over 70 years of age.
Within 1 year of diagnosis, 40-50% patientshave an amputation and 25% die.
How CLI leads to amputation?
Amputation occurs when there is marked ischemia of the limb owing to reduction of blood flow and increase demand in the limb.